Question (Q): What is the success rate of N.O. treatment?

Answer (A): The success rate will be known after phase II trials. So far, there are results from some patients who followed Dr. Ozel's recommended therapy scheme fully. Some such case reports are posted on this site.

Q: Which varieties of cancer is N.O. treatment efficacious on?

A: Dr. Ozel's opinion is that the efficacy of N.O. treatment does not depend on the variety of cancer, but rather on the immune system of each individual.

Q: Is Anvirzel the same as NOI?

A: Anvirzel ( Anti viral Ozel) is a trademark that was registered by Ozelle Pharmaceutical, Inc. (OPI) for NOI. There were some changes made in the production process, therefore, it can not be said that NOI and Anvirzel are similar.

Q: Why didn't we hear about N.O. treatment before?

A: Dr. Ozel first started to work with N.O. in 1966. He tried to call the attention on its merits many times (the events are summarized on the other pages of this site ). Before AIDS appeared, immunology was covered in just a single paragraph in medical textbooks. When the first cases were reported in 1970s, scientific community preferred to ignore or reject Dr. Ozel and his cases, because they could not understand, explain the mechanism of action of this drug. Later when immunology developed as a science, new tests were found, nerium oleander extracts could be tested, and its mechanism of action through the immune system could be witnessed (e.g. 27, 28, 29 ). But there is much room for further research to understand the details of the mechanism of action.

Q: What are the side effects of N.O. treatment?

A: The side effects of N.O. treatment are explained on the Materials & Method page of this site.

Q: I prepared the extract according to the formula given in your patent. However, the color turned out to be yellow rather than brown. I don’t understand how brown color would be obtained from green leaves and green stalks. Should the color be definitely brown? If your answer is yes, what am I supposed to do?

A: Let us assume that you did everything correctly; you filtered the extract correctly, you placed it in airtight containers, you sterilized it and put it in the refrigerator (2 – 4oC). Wait for one week. The color of the extract should turn brown. Do not use the extract if its color does not turn brown. If you use, it does not do any harm, but it does not do any good either.

Q: What kind of filter should I use? Are there any commercially available filters that you may recommend?

A: Pore size of the filter needs to be greater than 4 microns; otherwise active molecules are filtered out. Among others, here are two commercially available paper filters:
- VWR brand, qualitative or quantitative 454 filter papers. They had a diameter of 15 cm, they were sold in boxes of 50 or 100 filters.
- Eaton Dikeman, grade 613 (medium speed) filter papers. They also had a diameter of 15 cm, and were sold in boxes of 50 or 100 filters.

Q: In the formula described in Example 1 of your patent, you use 10 liters of distilled water for 2 kg of plant material. Thinking of a ratio of 1 to 5, I used 1 liter of distilled water for 200 grams of plant material. Is this correct? In such a case, do I need to change the boiling time described in the patent?

A: The ratio of 200 grams of plant material to 1 liter of distilled water is correct. What is important is to reach the appropriate density. Depending on the amount of extract and heating method, this may take from 1.5 hours to 5 hours.

Q: In the formula, there are waiting periods like 6 – 8 hours, 10 hours. Are these compulsory or allowed periods? I.e. do I have to sterilize after waiting six hours, or can I only wait for up to six hours?

A: The aim of the waiting period is to let the extract cool to room temperature. As a rule of thumb, if you can touch the extract container with your bare hands comfortably, i.e. if it is cold enough, then you may start filtering.

Q: I used about 150 grams of green healthy leaves and about 50 grams of fresh green stalks. What should be the leaves/stalks ratio?

A: That ratio was never measured. One chooses 20 – 60 cm parts of the growing ends of the branches of healthy nerium oleander plants; one uses the whole of the chosen part. (stalk of such parts are green like the leaves)

Q: Is the density measured hot?

A: Density is measured at room temperature.

Q: Is the plant material, which is collected, not washed?

A: The plant material is throughly washed with clean water until it is free of any dirt, dust, insects, etc...